Sugarcane, Rice and Fruiting vegetables are the ones most affected by Borers. Stem borers can destroy rice at any stage of the plant from seedling to maturity. They feed upon tillers and causes dead hearts or drying of the central tiller, during vegetative stage; and causes whiteheads at reproductive stage. Sugarcane stem borer caterpillars kill the plant growing points and cause “dead hearts” (the youngest still unfolded leaves wilt and die), they cause broken sugarcane stalks and reduced sugar contents in infested sugarcane crops. Emamectinbenzoate has a new mechanism of action and a strong activity against Borers as well as with and a high selectivity on useful organisms. This molecule acts if swallowed and has some contact action. It penetrates leaf tissues (translaminar activity) and forms a reservoir within the leaf. The mechanism of action is unique in the panorama of insecticides. Itinhibits muscle contraction, causing a continuous flow of chlorine ions in the GABA and H-Glutamate receptor sites. Emamectin has also shown promising applications in the eradication of fish lice and in fish farming. Cobra Advance has shown excellent control of Fruit borers in Brinjals, tomatoes and Cardamom.